I think there are quite a few companies like this in various countries, away from SF PR that we don't know about.
https://www.broadinstitute.org/about-us
https://broadinstitute.wd1.myworkdayjobs.com/broad_institute
I work there. My group builds scalable tools for genomic data analysis:
We're about to post two job reqs, for an SRE and front-end/design position. Email in my profile. Get in touch if you're interested.
gnomAD is the largest public dataset of human genetic variation:
https://gnomad.broadinstitute.org/
They recently a 7 paper collection in Nature: https://www.nature.com/collections/afbgiddede. They're also hiring an SRE:
https://broadinstitute.wd1.myworkdayjobs.com/en-US/broad_ins...
Lots of other jobs at various levels throughout the institute. Biology knowledge generally note required (I had none), although it helps (but be prepared to learn).
You won't find many. By definition what you're describing is incredibly expensive and without an immediate return. So the only groups that can afford work on these kinds of problems are academics, big companies with large R&D budgets or organizations like NASA or CERN. Any small company that attempts this will just go broke very quickly.